基于FOXO3a/Nrf2信號通路探討尿毒癥骨骼肌自噬的分子機制
重慶醫(yī)科大學(xué)學(xué)報
頁數(shù): 8 2024-08-19
摘要: 目的:探討叉頭盒(forkhead box,FOX)O蛋白3a(forkhead box O3a,FOXO3a)/轉(zhuǎn)錄因子NF-E2相關(guān)因子2(nuclear factor erythroid 2-related factor 2,Nrf2)信號通路的調(diào)節(jié)尿毒癥骨骼肌自噬的機制。方法:24只小鼠隨機分為假手術(shù)組(Sham組)、慢性腎病(chronic kidney diseas...