熱休克蛋白的生物學(xué)功能及其對細(xì)胞的輻射防護(hù)作用

摘要： 熱休克蛋白(HSPs)是細(xì)胞在受到刺激后產(chǎn)生的非特異性保護(hù)蛋白,參與細(xì)胞的損傷修復(fù)。本文介紹了熱休克蛋白的分類及其分子生物學(xué)特性,概述了其分子伴侶、抗細(xì)胞凋亡、抗氧化功能等細(xì)胞保護(hù)作用的機(jī)制,從射線誘導(dǎo)HSPs表達(dá)、抗輻射誘導(dǎo)的細(xì)胞凋亡、DNA損傷防護(hù)等方面總結(jié)了HSPs的輻射防護(hù)作用。HSPs有可能成為新一代輻射損傷防護(hù)劑。
Heat shock proteins(HSPs) are nonspecific protective proteins produced by cells after receiving stress stimulation which participate in cell damage repair.This article introduced classification of heat shock proteins and their molecular biological features,and outlined the mechanisms of their protective functions for cells,such as molecular chaperones,antiapoptosis and antioxidation.This article also summarized radiation protective functions of heat shock proteins from following aspects: rays induce the expression of heat shock proteins,resisting cell aopoptosis induced by radiation and DNA damage protection.Heat shock proteins have the potential of being a new generation protective agent against radiation damage.