大鼠接受不同運動刺激后高嶺土攝取量分析(英文)

摘要： 目的分析選擇不同運動方式作用于大鼠的前庭感受器后,誘導高嶺土攝取量變化作為運動病指標的有效性。方法大鼠隨機分成5組,其中3組分別經(jīng)過沿耳間軸(IA)、頭尾軸(AP)進行的直線加速運動和雙軸旋轉運動(DR)刺激,另2組用于對照組。實驗時記錄刺激前、后各3d的高嶺土攝取量,并對數(shù)據(jù)做統(tǒng)計學分析。結果本研究觀察到:1)進行IA、AP和DR刺激后,上述各組分別有25%、17%和58%的大鼠在刺激后3d高嶺土攝取量較之刺激前3d的平均增加1g以上;2)與有些報道不同,本研究中刺激后高嶺土攝取量的增加持續(xù)1d以上。結論3種運動刺激模式均可作為選擇性刺激前庭感受器官后誘導大鼠增加攝取高嶺土的方法,其中雙軸旋轉運動刺激最為有效。
Objective To analyze the efficacy of kaolin intake amount as an index for motion sickness(MS)induced by different motion patterns stimulating the vestibular receptors of rats.Methods Rats were randomly divided into 5 groups.Three groups were subjected to one of the following stimulations,respectively-linear acceleration along either the interaural axis(IA)or body axis(AP),and double rotation(DR)stimulation.Other 2 groups were used as control.Kaolin intake was recorded for consecutive 6 d,3 d before and 3 d after stimulation,and the data were statistically analyzed.Results It was found that:1)following IA,AP and DR stimulations,25%,17% and 58% of the rats in each group increased mean kaolin intake by 1 g in the 3 d phase post-stimulation compared with that in the same duration of pre-stimulation,respectively;2)in contrast to some previous reports,the present observation showed that high level of kaolin intake post-stimulation may persist for more than one day.Conclusion All 3 types of stimulation methods can serve as ways of specifically stimulating vestibular end-organs to induce kaolin intake increase,and double rotation is the most effective.